Molecular Microscope Lets Scientists Peer Inside Single Cells
Knowing how proteins behave inside individual human cells can tell us whether those cells will live, die or malfunction—information that can serve as an early warning of disease. But such detailed information is hard to come by because today’s analytical methods require minimum samples of hundreds to thousands of cells. Now, however, researchers at Pacific Northwest National Laboratory (PNNL) have developed a “molecular microscope” for detecting and identifying proteins within samples of only a few cells—or even a single cell—and have used it to distinguish between diseased and healthy tissue....